Guide to liver supplements

Support your body’s natural filter with healthy liver supplements

Have you ever used an air or water purifier? By filtering the elements you take in, you eliminate harmful particles and toxins from your body. Just like air conditioners, vacuum cleaners, and other devices have filters, your body has its own filtering system.

Your liver filters your body’s entire blood supply and is involved in blood clotting, blood sugar, and more. The liver supports every part of your body, and you can support it with healthy liver supplements to promote your body’s natural processes, like methylation.

What is methylation?

Methylation is a biochemical process where bioactive compounds transfer methyl groups, which are structures of one carbon and three hydrogen molecules. A compound becomes “methylated” when a protein, hormone, or enzyme receives a methyl group.

These methylated compounds produce DNA, red blood cells, neurotransmitters, hormones, amino acids, and more, impacting every part of the body, from the heart to the brain to the reproductive organs. Methylation is also essential for detoxing the liver.

Methylation and the liver

So how does this all affect the liver? The body uses methylation to “tag” toxic substances and convert them into water-soluble forms to be processed by the liver and eliminated through sweat and urine. Without this process, the liver can’t do its job, and toxins will build up in the body, hence why the best supplements for detoxing the liver often focus on the methylation process.

Supplements for a healthy liver

Your liver is essential, yet about 4.5 million adults in the U.S. (1.8%) have liver disease, with the Centers for Disease Control estimating that many more remain unaware of liver issues. Many existing studies researched those with liver issues to establish a possible link between these healthy liver supplements, diet and optimal liver function.

Vitamin B6

One of the liver’s primary functions is breaking down fat to produce energy, and vitamin B6 plays a key role in the enzyme systems and metabolizing fat. In one study, the administration of vitamin B6 significantly reduced fat accumulation in the liver, pointing to a possible role in nonalcoholic fatty liver disease.  

Vitamin B12

Vitamin B12 helps form red blood cells, DNA, brain cells, and nerve cells. This vitamin also helps metabolize proteins and lipids, a type of fatty acid. In one study, vitamin B12 acted as a healthy liver supplement by decreasing hyperhomocysteinemia (too much of a specific amino acid in your blood). Another study noted that vitamin B12 and folate can reduce liver thickening and inflammation.


Riboflavin, or vitamin B2, is a component of the coenzymes involved in energy production, cell growth, and fat breakdown. As a healthy liver supplement, it acts as an antioxidant and anti-inflammatory. Several studies associate riboflavin with the liver, with one study showing Vitamin B2s ability to delay hepatic fibrosis or the buildup of excessive connective tissue. Another study discovered that riboflavin deficiency depresses growth and causes fat accumulation in the liver.


Betaine is a compound that occurs naturally in plants and the body. It’s involved in cell reproduction and liver function and can reverse inflammation, fibrosis, and fatty liver disease. It can also protect the liver against various impairments caused by endotoxins, chemicals, and alcohol.


Glutathione is a peptide – a short chain of amino acids – with powerful properties. The liver also produces it as an antioxidant to eliminate poisons and protect the body against free radicals and pollutants. Glutathione is crucial to the methylation and detoxification processes and can treat acute poisoning and chronic liver disease.

Keeping your liver healthy

Even the best supplements for detoxing the liver are no substitute for a healthy lifestyle. A healthy diet with plenty of fruits and vegetables, whole grains, nuts, and fish will help your liver get all the nutrients it needs. Exercise maintains a healthy body weight, putting less strain on your organs and lowering your risk of nonalcoholic fatty liver disease. Drink plenty of water and cut back on alcohol, which strains your liver by forcing it to stop its other functions to break down the toxins.

Supplements for a healthy liver are a good choice for those who want additional support for one of their body’s largest organs. Tony Robbins’ Methylation supplement is a unique blend of high-quality ingredients that helps your body fight oxidative stress and supports brain, heart, and liver health, allowing your liver to provide effective support.* 

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Team Tony

Team Tony cultivates, curates and shares Tony Robbins’ stories and core principles, to help others achieve an extraordinary life.

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